Immediate effect. Helps reduce pimples within 4 hours. Helps keep stains away - with daily use. Clean & Clear Advantage Spot Treatment Gel is clinically proven to dissolve stains in just 4 hours. Its unique formula with stain-fighting ingredients quickly regulates oil, helps against problematic bacteria and effectively cleanses the skin without irritating or drying. After 4 hours, punctual size and redness are noticeably reduced.